Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats

Authors

  • Desheng Wang Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
  • Jingkun Zhao Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
  • Liming Zhang Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
  • Ruihong Sun Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
  • Shurong Duan Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Abstract:

Objective(s):To investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. Materials and Methods:Male Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa’s method, and reperfusion was allowed after 2 hr occlusion. Mild hypothermia (33±0.5℃) for 6 hr was initiated at the start of reperfusion. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3. Results: Infarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P

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Journal title

volume 17  issue 6

pages  454- 459

publication date 2014-06-01

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